Sex-dependent gene regulatory networks of the heart rhythm
نویسندگان
چکیده
منابع مشابه
Analysis of Gene Regulatory Networks in the Mammalian Circadian Rhythm
Circadian rhythm is fundamental in regulating a wide range of cellular, metabolic, physiological, and behavioral activities in mammals. Although a small number of key circadian genes have been identified through extensive molecular and genetic studies in the past, the existence of other key circadian genes and how they drive the genomewide circadian oscillation of gene expression in different t...
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While the molecular mechanisms of glucocorticoid regulation of transcription have been studied in detail, the global networks regulated by the glucocorticoid receptor (GR) remain unknown. To address this question, we performed an orthogonal analysis to identify direct targets of the GR. First, we analyzed the expression profile of mouse livers in the presence or absence of exogenous glucocortic...
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Introduction: The major issue for the future of bioinformatics is the design of tools to determine the functions and all products of single-cell genes. This requires the integration of different biological disciplines as well as sophisticated mathematical and statistical tools. This study revealed that data mining techniques can be used to develop models for diagnosing high-risk or low-risk lif...
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ژورنال
عنوان ژورنال: Functional & Integrative Genomics
سال: 2009
ISSN: 1438-793X,1438-7948
DOI: 10.1007/s10142-009-0137-8